{"product_id":"antaeus-labs-aegis-180-capsules","title":"Antaeus Labs: Aegis, 180 Capsules","description":"\u003cspan data-mce-fragment=\"1\"\u003eAntaeus Labs: AEGIS\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eThere are many types of liver injury, but only one is normally associated\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003ewith the use of oral androgens -- cholestasis. This condition is defined as\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003ea failure of normal bile to reach the duodenum, which may be due to a\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003enumber of different pathological states between the hepatocyte and the\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eampulla of Vater. When one takes oral androgens (typically methylated at\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eC17a) the physical structure of the hepatocyte is altered -- microfilaments\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eand canaliculi become less contractile. Disruptions in the canalicular bile\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003esalt export pump may also occur. This leads to impaired bile flow and the\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eretention of highly cytotoxic hydrophobic bile salts. At low\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003econcentrations, these retained bile salts cause apoptosis; at higher\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003econcentrations, necrosis and severe liver damage.\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eThis is where AEGIS comes into the picture. It was designed with users of\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eoral androgens in mind, and brings together the best anti-cholestatic\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eingredients available.\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eTauroursodeoxycholic acid:\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e-Can prevent apoptosis during cholestasis. Toxic bile acids produce\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eapoptosis Via fas- and TRAIL- death receptor mediated pathways. Both are,\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eto some degree, dependent on the translocation of the 'bax' pro-apoptoic\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003emolecule from the cytosol of hepatocytes to the cell mitochondria. TUDCA\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eprevents bax translocation, strongly stabilizes mitochondrial membranes,\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eand activates the MAPK pro-survival pathway in hepatocytes.\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e(ref\u0026lt;\u003c\/span\u003e\u003ca href=\"http:\/\/www.jlr.org\/content\/50\/9\/1721.full.pdf\" data-mce-fragment=\"1\" data-mce-href=\"http:\/\/www.jlr.org\/content\/50\/9\/1721.full.pdf\" target=\"_blank\"\u003ehttp:\/\/www.jlr.org\/content\/50\/9\/1721.full.pdf\u003c\/a\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u0026gt;)\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eThese effects protect hepatocytes from bax-related apoptosis.\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e-Is a hydrophilic bile acid, and its presence markedly shifts the bile pool\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003etowards hydrophilicity, which, to some extent, detoxifies it. When used\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003econsistently, especially at pharmacological doses, TUDCA (along with UDCA)\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eeventually becomes the predominant bile acid in the liver and in general\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003ecirculation. (ref\u0026lt;\u003c\/span\u003e\u003ca href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2036.1999.00596.x\/pdf\" data-mce-fragment=\"1\" data-mce-href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2036.1999.00596.x\/pdf\" target=\"_blank\"\u003ehttp:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2036.1999.00596.x\/pdf\u003c\/a\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u0026gt;\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e)\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e-Directly stimulates bile secretion via modulating cellular signalling\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003epathways in hepatocytes, such as ERK, src, PKC and others. These signalling\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003epathways generally phosphorylate, or activate, the bile salt export pump\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e(BSEP) and other processes involved in bile export\/secretion. (For example,\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003ePKC-alpha-mediated secretion of HCO3-.)\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e(ref\u0026lt;\u003c\/span\u003e\u003ca href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12730886?dopt=Abstract\u0026amp;holding=npg\" data-mce-fragment=\"1\" data-mce-href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12730886?dopt=Abstract\u0026amp;holding=npg\" target=\"_blank\"\u003ehttp:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12730886?dopt=Abstract\u0026amp;holding=npg\u003c\/a\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u0026gt;\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e, ref\u0026lt;\u003c\/span\u003e\u003ca href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2589332\/pdf\/yjbm00029-0062.pdf\" data-mce-fragment=\"1\" data-mce-href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2589332\/pdf\/yjbm00029-0062.pdf\" target=\"_blank\"\u003ehttp:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2589332\/pdf\/yjbm00029-0062.pdf\u003c\/a\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u0026gt;\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e, ref \u0026lt;\u003c\/span\u003e\u003ca href=\"http:\/\/www.nature.com\/labinvest\/journal\/v86\/n2\/full\/3700371a.html\" data-mce-fragment=\"1\" data-mce-href=\"http:\/\/www.nature.com\/labinvest\/journal\/v86\/n2\/full\/3700371a.html\" target=\"_blank\"\u003ehttp:\/\/www.nature.com\/labinvest\/journal\/v86\/n2\/full\/3700371a.html\u003c\/a\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u0026gt;)\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003ePolyenylphosphatidylcholine:\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e-Stabilizes cellular membranes and dilates bile canaliculi. This former\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eeffect has been shown to protect human cells from hydrophobic bile salt\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003einduced apoptosis\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e(ref\u0026lt;\u003c\/span\u003e\u003ca href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12730886?dopt=Abstract\u0026amp;holding=npg\" data-mce-fragment=\"1\" data-mce-href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12730886?dopt=Abstract\u0026amp;holding=npg\" target=\"_blank\"\u003ehttp:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12730886?dopt=Abstract\u0026amp;holding=npg\u003c\/a\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u0026gt;\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e), and the latter may serve to counteract the reduction in contractility\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eseen in androgen-induced cholestasis.\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e(ref\u0026lt;\u003c\/span\u003e\u003ca href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/706511\" data-mce-fragment=\"1\" data-mce-href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/706511\" target=\"_blank\"\u003ehttp:\/\/www.ncbi.nlm.nih.gov\/pubmed\/706511\u003c\/a\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u0026gt;\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e)\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e-Oral androgen administration may decrease hepatic Na+, K+-ATPase, Ca2+, Mg\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e2+-ATPase and F-actin levels --- all of which may be restored, and even\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eraised, by polyenylphosphatidylcholine administration.\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e(ref\u0026lt;\u003c\/span\u003e\u003ca href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0024320503002923\" data-mce-fragment=\"1\" data-mce-href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0024320503002923\" target=\"_blank\"\u003ehttp:\/\/www.sciencedirect.com\/science\/article\/pii\/S0024320503002923\u003c\/a\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u0026gt;\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e)\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e-Is secreted into bile by hepatocytes, where it serves as a major component\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eof the micelles in which bile acids are emulsified. Increased levels of\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003ebiliary phosphatidylcholine reduces the cytotoxicity of bile acids, whereas\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003ephosphatidylcholine-secretion impairment (as is often seen in ABCB4\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003edisease) is characterized by extremely severe cholestatic liver disease. (\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eref \u0026lt;\u003c\/span\u003e\u003ca href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19273348\" data-mce-fragment=\"1\" data-mce-href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19273348\" target=\"_blank\"\u003ehttp:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19273348\u003c\/a\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u0026gt;)\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eTo summarize: Aegis is highly-potent, highly-specific liver protection for\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003epeople taking hepatotoxic oral androgens. Superior protection cannot be\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003ebought, nor should it be needed.\u003c\/span\u003e","brand":"lockoutsupplements","offers":[{"title":"Default Title","offer_id":43995634598110,"sku":"46670","price":36.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0621\/1266\/1726\/products\/antaeus-labs-aegisjpg.image.102x200.jpg?v=1676497961","url":"https:\/\/lsresearch.store\/products\/antaeus-labs-aegis-180-capsules","provider":"LSResearch","version":"1.0","type":"link"}