LGI TB-4, BCP-157 Stack

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TB4 and BPC Stack!

TB4-Frag, also known as Thymosin Beta 4 Fragment, is a bioactive fragment from thymosin beta-4 (TB4), a naturally occurring peptide. It is suggested to support regenerative and immune-modulating processes.

Reported benefits of TB4-Frag include support for tissue repair and regeneration, reduced inflammation, and enhanced immune system response. Additional potential benefits listed are gut health support, contribution to addressing fibrosis, support for skin health, mitochondrial support, antimicrobial properties, and enhanced athletic recovery.

TB4-Frag is said to enhance cellular repair and regeneration by interacting with actin. It is typically taken orally in capsule form. Some sources suggest it is considered more potent than full-length TB4.

What is it?

TB4-Frag is a smaller, active part of Thymosin Beta-4, a peptide found naturally in the body.
It's designed to provide the benefits of full-length TB4 in a more potent and targeted form.
A specific fragment, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), which is a tetrapeptide (four amino acids), is derived from TB4 and exhibits anti-inflammatory, pro-angiogenic (promoting new blood vessel growth), and anti-scarring properties.

Potential benefits

Tissue repair and regeneration: It may enhance the body's natural healing processes and support the repair of muscles, ligaments, and fascia. It has been linked to accelerated wound healing and improved recovery from injuries.
Inflammation reduction: It may help balance cytokine inflammation and mitigate inflammatory reactions. It is thought to prevent the activation of inflammatory cells, thus speeding up the repair process.
Immune system support: It may strengthen the immune response and suppress mast cell activation, potentially offering relief from allergic reactions. It's involved in modulating the immune system and producing antibodies.
Cardiovascular health: It may boost cardiovascular cell recovery and help the body address clots. Studies suggest it may promote angiogenesis (new blood vessel formation) and improve cardiac function after coronary artery ligation in animal models.
Neurological benefits: It may help prevent cell death and promote regeneration, potentially being useful after traumatic brain injury. The fragment Ac-SDKP has been shown to increase hippocampal neurogenesis and improve spatial memory in animal models. It also appears to protect against the toxic effects of chemotherapy and radiation therapy on bone marrow.
Gut health: It may enhance gut health and play a role in addressing fibrosis and "inflammaging" (inflammation associated with aging). It may help prevent or treat inflammatory bowel diseases like Crohn's disease and ulcerative colitis.

Distinction from full-length TB4

Full-length TB4 may not absorb orally or nasally due to its size, while the shorter TB4-Frag is absorbed orally.
TB4-Frag may be more potent and targeted, potentially eliminating side effects like mast cell activation and hair growth stimulation, which have been associated with a specific segment of full-length TB4.

In summary, TB4-Frag is a derivative of Thymosin Beta-4, a peptide with a wide range of potential benefits, especially in promoting healing, reducing inflammation, and supporting the immune system. Various forms and formulations are available, and consulting with a healthcare professional is advisable before incorporating it into one's health regimen.

BPC-157 is a natural protein found in the human stomach and digestive tract. Most proteins are broken down in the stomach and are reduced to their amino acid constituent parts -- which is why the oral delivery of protein drugs such as insulin has thus far been effectively impossible -- but BPC-157 is, surprisingly, highly stable and orally bioavailable. It has been surmised that it functions as an endogenous anti-ulcer agent and angiogenic growth promoter, and that its primary site of action is the digestive tract.

Yet supplementation with BPC-157 has been shown to improve overall wound healing [1], improve ligament healing [2], improve tendon healing and increase HGH receptor expression in recovering tendon injuries [3], accelerate muscle recovery from crush injuries [4], accelerate soft tissue recovery, [6] and more. In all cases, it was delivered orally. It appears to mediate these effects by increasing growth factor expression -- e.g. HGH receptor expression -- at injury sites. [6, 7]

The "BPC" stands for body protection compound, and, true to its name, there's no more potent natural compound for tendon, ligament, and muscle recovery.

[1] Seiwerth, S., Milavic, M., Vukojevic, J., Gojkovic, S., Krezic, I., Vuletic, L. B., Pavlov, K. H., Petrovic, A., Sikiric, S., Vranes, H., Prtoric, A., Zizek, H., Durasin, T., Dobric, I., Staresinic, M., Strbe, S., Knezevic, M., Sola, M., Kokot, A., … Sikiric, P. (2021). Stable gastric pentadecapeptide bpc 157 and wound healing. Frontiers in Pharmacology, 12, 627533. https://doi.org/10.3389/fphar.2021.627533

[2] Cerovecki, T., Bojanic, I., Brcic, L., Radic, B., Vukoja, I., Seiwerth, S., & Sikiric, P. (2010). Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society, 28(9), 1155–1161. https://doi.org/10.1002/jor.21107

[3] Japjec, M., Horvat Pavlov, K., Petrovic, A., Staresinic, M., Sebecic, B., Buljan, M., Vranes, H., Giljanovic, A., Drmic, D., Japjec, M., Prtoric, A., Lovric, E., Batelja Vuletic, L., Dobric, I., Boban Blagaic, A., Skrtic, A., Seiwerth, S., & Predrag, S. (2021). Stable gastric pentadecapeptide bpc 157 as a therapy for the disable myotendinous junctions in rats. Biomedicines, 9(11), 1547. https://doi.org/10.3390/biomedicines9111547

[4] Novinscak, T., Brcic, L., Staresinic, M., Jukic, I., Radic, B., Pevec, D., Mise, S., Tomasovic, S., Brcic, I., Banic, T., Jakir, A., Buljat, G., Anic, T., Zoricic, I., Romic, Z., Seiwerth, S., & Sikiric, P. (2008). Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat. Surgery Today, 38(8), 716–725. https://doi.org/10.1007/s00595-007-3706-2

[5] Seiwerth, S., Rucman, R., Turkovic, B., Sever, M., Klicek, R., Radic, B., Drmic, D., Stupnisek, M., Misic, M., Vuletic, L. B., Pavlov, K. H., Barisic, I., Kokot, A., Japjec, M., Blagaic, A. B., Tvrdeic, A., Rokotov, D. S., Vrcic, H., Staresinic, M., … Sikiric, P. (2018). Bpc 157 and standard angiogenic growth factors. Gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing. Current Pharmaceutical Design, 24(18), 1972–1989. https://doi.org/10.2174/1381612824666180712110447

[6] Gwyer, D., Wragg, N. M., & Wilson, S. L. (2019). Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell and Tissue Research, 377(2), 153–159. https://doi.org/10.1007/s00441-019-03016-8

[7] Chang, C.-H., Tsai, W.-C., Hsu, Y.-H., & Pang, J.-H. S. (2014). Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules (Basel, Switzerland), 19(11), 19066–19077. https://doi.org/10.3390/molecules191119066